Poprzedni temat «» Następny temat
Autor Wiadomość
koksik844

SOGI: 1130

MASTER


Pomógł: 2 razy
Dołączył: 11 Sie 2008
Posty: 1130
Skąd: Poznań
  Wysłany: Wto Sty 06, 2009 8:10 pm     

nie widziales promo ? 3szt zola za jedyne 300pln!
nic tylko brac!
 
 
   
nrw

SOGI: 2147479409

pitbullshop

Pomógł: 14 razy
Dołączył: 16 Lip 2008
Posty: 2571
  Wysłany: Czw Sty 08, 2009 3:21 pm     

Za 4 tyg firma Applied Nutriceuticals wypusci The ONE



Name: 17a-methyl-etioallocholan-17b-ol-3-hydroxyimine

Standard: Testosterone

Androgenic: 140

Anabolic: 380

Estrogenic Activity: none

Progestational Activity: none

Derivation/Analog of: Dihydrotestosterone
_________________
Оптовий гендель якнайменші ціни в Європі
 
 
   
koksik844

SOGI: 1130

MASTER


Pomógł: 2 razy
Dołączył: 11 Sie 2008
Posty: 1130
Skąd: Poznań
  Wysłany: Czw Sty 08, 2009 6:04 pm     

nrw prosze bardziej po polsku :) bo jakos te wzory mi nie leza.. heh
do czego mozna to porownac ?
 
 
   
Gurth

SOGI: 117

Moderator

Pomógł: 1 raz
Dołączył: 06 Gru 2007
Posty: 109
  Wysłany: Czw Sty 08, 2009 9:26 pm     

Product Characteristics:

• The One is an oral prohormone of Dihydrotestosterone (DHT), a compound that produces effects 3 to 5 times more potent than testosterone on the androgen receptor.
• The One can inhibit the action of estrogens by acting as a competitive antagonist and/or decreasing the mRNA-induced transcription of estrogenic effects post-binding.
• The One can also act like an aromatase inhibitor, disallowing the conversion of androgens to estrogen.
• The One activates GLUT-4 receptors in skeletal muscle, increasing glycogen uptake of 17-alpha alkylated molecules for greater oral bioavailability.
• The One can significantly lower SHBG levels, allowing for more active product to reach skeletal muscle.

Effects Related to Physique Enhancement:

• Rapid lean body mass gains - typical users report 0.75 lb./day gains for first 2-3 weeks
• Overall hardening effect to physique
• Increased vascularity
• Increased strength
• Dramatically enhanced neural function (coordination) as DHT is the predominant androgen in neural function
• Mood-enhancing effect
• Lipolytic effect (increases fat metabolism)

ADMINISTRATION/DOSAGE:
• Effective dose: 67.5 - 90 mg/day (3-4 capsules) ; DO NOT EXCEED 90 MG/DAY
• Can be taken with or without food; preferably in the AM
• Oral Administration Only
• 4-5 week administration period; do not exceed 5 weeks duration

Mechanism of Action/Function:

Absorption
• User ingests compound orally
• Digestion occurs in roughly 20-30 minutes (as with most encapsulated products)
• Compound is absorbed by the duodenum and jejunum of the small intestine, and then is displaced into the hepatic portal vein, (a special blood vessel leading from the digestive tract to the liver) where the compound must undergo the “first pass” through the liver and survive hepatic metabolism.
• Methylation allows the compound to survive the first pass through the liver, protecting the molecule from hepatic enzymatic degradation.
• After first pass, the compound is distributed into the inferior vena cava, and then to the heart for systemic distribution.

Distribution
• The heart pumps the active compound into all different areas of the body during the distribution phase. As is the case with most compounds, SHBG (steroid hormone binding globulin) can remove active compounds from systemic distribution before they reach their target organ (in this case, skeletal muscle).
• Binding proteins such as SHBG are rendered fairly inactive in this situation with the active ingredient in The One, because it is one of only a few compounds that does not carry an actual 3-keto group; it carries a 3-oxime group instead.
• Research has dictated that oximes have little or no binding affinity to SHBG in the blood stream, allowing for more free active substrate to reach their target (the androgen receptor (AR) in skeletal muscle). In essence, the 3-oxime “protects” the molecule from being bound (see graph below) leaving more active substrate in the blood to target skeletal muscle.

Metabolism
• Once The One reaches skeletal muscle, it must interact with specific target androgen receptors to exert the desired effect of increased protein synthesis and increased nitrogen retention.
• Under normal circumstances, DHT is quickly deactivated in the blood by 3a-HSD into 5alpha-androstan-3a,17b-diol, a weak androgen, and its access to target skeletal muscle tissue is restricted.
• There is some evidence that the 3-oxime substituted for 3-keto group may slow this deactivation, allowing for greater binding of the molecule to the AR.
• Oximes are a group of compounds with the general formula R¹R²CNOH, where R1 constitutes an organic side chain, and R2 is another organic group. This forms a ketoxime.
• Oximes exist as two geometric stereoisomers: a syn-isomer and an anti-isomer.
• Oximes are formed by the action of hydroxylamine on ketones.

Receptor Binding
• Because the evidence suggests that active DHT may not be metabolized by 3a-HSD into the weaker 5-alpha-androstan-3a,17b-diol within the skeletal muscle because of the oxime, there is a very good chance that fairly large amounts of DHT will actually bind to the AR in skeletal muscle.
• DHT has a 3 to 5 times greater binding potency on the androgen receptor than testosterone, so the resulting effect from The One is a very powerful growth stimulus on skeletal muscle.
• Androgens can act in a genomic (transcriptive, from direct AR binding) or non-genomic (non-AR binding) fashion on target cells.
• Some examples of non-genomic effects: increased IGF-1 expression, displacement of estrogen and progesterone from receptor sites, displacement of aromatase, and increased uptake of calcium in the sarcoplasmic reticulum.

Genomic Effects and MOA:
• The AR has four functional regions: a hinge region containing a nuclear localization signal, a carboxy-terminal ligand-binding domain (AF-2 site), an amino terminal regulatory domain (AF-1 site) and a DNA-binding domain composed of two zinc fingers.
• ARs that are not ligated are located primarily in the cytoplasm, and are bound to heat shock proteins (HSPs). HSPs stabilize the tertiary structure of the AR, permitting androgen binding.
• When The One binds the AR, there is a resulting dissociation of HSPs from the AR, allowing for dimerization (to be held together by molecular force) of the AR and subsequent tyrosine kinase phosphorylation, resulting in translocation (movement) of the AR to the nucleus.
• When the AR translocates inside the nucleus, it binds androgen response elements located in the enhancer and promoter areas of target genes. This results in the consequential assembly of regulatory proteins, and the creation of an active complex for transcription.
• The regulatory proteins form a cross-bridge with the AR, the RNA polymerase, and the pre-initiation complex. Specific coactivators begin transcription by recruiting protein clusters to DNA that change the chromatin scaffolding to a form that is more active for transcription.
• The resulting activated transcription results in synthesis of mRNA, which is signaled by ribosomes to produce specific proteins. Changes in specific cell proteins follow, which in turn mediate growth responses, nitrogen balance, and protein synthesis, among other things.

Excretion
• The Compound is removed from the body via excretion, through the kidneys via glomelular filtration.

siła reklamy
zgłaszam sie do testowania :D
 
 
   
donpitbull

SOGI: 3289

MASTER


Pomógł: 11 razy
Dołączył: 29 Wrz 2008
Posty: 1651
  Wysłany: Czw Sty 08, 2009 9:33 pm     

Gurth a jednym zdaniem jak byś to określił :?:
_________________
Dopóki walczysz, jesteś zwycięzcą.
 
 
   
Gurth

SOGI: 117

Moderator

Pomógł: 1 raz
Dołączył: 06 Gru 2007
Posty: 109
  Wysłany: Czw Sty 08, 2009 9:36 pm     

metylowany, pochodnia dht
przypomina m-drol
Ostatnio zmieniony przez Gurth Czw Sty 08, 2009 9:38 pm, w całości zmieniany 1 raz  
 
 
   
koksik844

SOGI: 1130

MASTER


Pomógł: 2 razy
Dołączył: 11 Sie 2008
Posty: 1130
Skąd: Poznań
  Wysłany: Czw Sty 08, 2009 9:37 pm     

dzieki za info

kuran kusi.. ciekawe jak cenowo, ale tez zaczyna mi slinka cieknac :wink:
Ostatnio zmieniony przez koksik844 Czw Sty 08, 2009 9:37 pm, w całości zmieniany 1 raz  
 
 
   
donpitbull

SOGI: 3289

MASTER


Pomógł: 11 razy
Dołączył: 29 Wrz 2008
Posty: 1651
  Wysłany: Czw Sty 08, 2009 9:37 pm     

no i o to mi chodziło.
teraz tylko trzeba przetestować 8)
_________________
Dopóki walczysz, jesteś zwycięzcą.
 
 
   
Gurth

SOGI: 117

Moderator

Pomógł: 1 raz
Dołączył: 06 Gru 2007
Posty: 109
  Wysłany: Pon Sty 19, 2009 8:37 pm     


60 Capsules

Serving Size1Capsule
Servings Per Container60

Ingredient % Daily Value*

Nasty Mass

13-Ethyl-3-Methoxy-Gona-2, 5(10)-Diene-17-One 25mg *
17a-Methyl-Etioallocholan-2-Ene-17b-Ol 10mg *

InSLINsified™ Proprietary Insulin Mimetic 250.5mg *
Fenugreek Seed (Trigonella Foenum-Graecum)(Seed) *
ALA (Alpha Lipoic Acid) *
Cinnamon Bark Extract (Cinnamonum Verum) *
Chromium Picolinate

plex, max lmg i dodatki



Serving Size1Capsule
Amount Per Serving % Daily Value
Epithiopropional Proprietary Matrix 40mg *
(Estra-4 9-Diene-3 17-Dione, 2a, 17a-Dimethyl-5-Androst-3-One, 2a, 3a-Epithio-17a-Methyletioallocholanol)

Liver Shield Proprietary Blend 175mg *
(Milk Thistle, Alpha Lipoic Acid, N-Acetyl Cysteine)

* % Daily Value not established

finigenX magnum, superdrol, epi
 
 
   
koksik844

SOGI: 1130

MASTER


Pomógł: 2 razy
Dołączył: 11 Sie 2008
Posty: 1130
Skąd: Poznań
  Wysłany: Pon Sty 19, 2009 8:53 pm     

ooo ale mieszanka :D
w usa stosuje juz to ktos ? widziales jakies recenzje ?
 
 
   
nrw

SOGI: 2147479409

pitbullshop

Pomógł: 14 razy
Dołączył: 16 Lip 2008
Posty: 2571
  Wysłany: Czw Sty 22, 2009 11:21 am     

Recenzji jeszcze nie ma to nowe produkty
_________________
Оптовий гендель якнайменші ціни в Європі
 
 
   
nrw

SOGI: 2147479409

pitbullshop

Pomógł: 14 razy
Dołączył: 16 Lip 2008
Posty: 2571
  Wysłany: Czw Sty 22, 2009 11:25 am     


_________________
Оптовий гендель якнайменші ціни в Європі
 
 
   
nrw

SOGI: 2147479409

pitbullshop

Pomógł: 14 razy
Dołączył: 16 Lip 2008
Posty: 2571
  Wysłany: Czw Sty 22, 2009 11:29 am     



_________________
Оптовий гендель якнайменші ціни в Європі
 
 
   
nrw

SOGI: 2147479409

pitbullshop

Pomógł: 14 razy
Dołączył: 16 Lip 2008
Posty: 2571
  Wysłany: Czw Sty 29, 2009 9:11 pm     

Tak sie prezentuja nowosci z Applied

_________________
Оптовий гендель якнайменші ціни в Європі
 
 
   
Gurth

SOGI: 117

Moderator

Pomógł: 1 raz
Dołączył: 06 Gru 2007
Posty: 109
  Wysłany: Czw Sty 29, 2009 9:47 pm     

moge przetestować :D jak tylko dojdzie Cycle Assist
 
 
   
Wyświetl posty z ostatnich:   
Odpowiedz do tematu
Nie możesz pisać nowych tematów
Nie możesz odpowiadać w tematach
Nie możesz zmieniać swoich postów
Nie możesz usuwać swoich postów
Nie możesz głosować w ankietach
Nie możesz załączać plików na tym forum
Możesz ściągać załączniki na tym forum
Dodaj temat do Ulubionych
Wersja do druku

Skocz do:  

Powered by phpBB modified by Przemo © 2003 phpBB Group

theme by chariot.pl
Strona wygenerowana w 0,35 sekundy. Zapytań do SQL: 10